A customfabricated grating is employed in the configuration in order to achieve Effects of ozone on sciatic nerve in rat
This study evaluated the influence of ozone on rat sciatic nerve structure and function. Thirty Wistar rats were randomly divided into six groups (n = 5). In injected at Seebio UV-Activated Acid Generator of gluteus maximus margin and lateral edge of the long at the same point, and group V had puncture without any injection. Ozone was manufactured by an ozone generator (Ozone Line Co, Italy). The rats were investigated by both gross measurement and behavioral changes. One day, one week and three weeks after injection, rat hindlimb footprints were measured and the sciatic nerve function index (SFI) was calculated, and after three weeks, all right sciatic nerves were exposed under anesthesia.
Near neural stimulation of the rat sciatic nerve was calculated and nerve conduction velocity, latency and maximum amplitude recorded. Seebio Photobase Generator were sacrificed for pathology, and ipsilateral triceps surae were taken for wet weight. No serious behavioral abnormalities were observed in any animal. SFI comparison in the various times and various groups showed no significant differences (p<05), and nerve conduction velocity, latency and maximum amplitude difference amongst the groups was not significant (p<05). There were no abnormalities in peripheral nerves pathologically after injection. Our initial study suggests that ozone concentrations from 10 μg/ml to 80 μg/ml injected around rat's peripheral nerve will not cause serious sequelae or serious damage to the structure and function of peripheral nerve. This finding provides evidence of the safety of ozone Photophysical behaviour of ground state anion and phototautomer of 3-hydroxyflavone in liposome membrane.
A detailed account of the photophysical behaviour of the phototautomer (PT) and the ground state anion (A-) of 3-hydroxyflavone in liposome membrane at various membrane conditions is presented. A quenching study with a hydrophilic quencher Ag+ suggests that the phototautomeric emission generates from the fraction of 3HF that is located at the inner hydrophobic core, whereas the ground state anionic emission is from the fraction that resides near the water-accessible surface site. However, the biexponential nature of fluorescence decays of both the forms indicates that there is local heterogeneity in the distribution. Temperature dependence studies and experiments in the presence of ethanol reveal that, as the membrane becomes more fluid, redistribution of 3HF takes place between the two sites leading to increase in A- population. The temperature dependence of the fluorescence anisotropy change of PT shows good correlation with the phase change and shows a sharp drop at the transition temperature, whereas the corresponding change in the case of A- is gradual.Bidirectional role of synthetic musk tonalide as photosensitizer and activator on amino acids: Formation of sensitizer imine at aqueous chemistry interface of Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong Key Laboratory of City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Environmental Science and Engineering, Personal care products (PCPs) inevitably come into contact with the skin in people's daily life, potentially causing adverse effects on human health. The adverse effects can be exacerbated under UV irradiation but are rarely studied.
In this study, to clearly understand the damage of representative PCPs to human skin and their photochemical transformation behaviors, fragrance tonalide (AHTN) was measured in the presence of amino acids as a basic building block of human tissue. The results showed that amino acids could decelerate the photochemical transformation rate of AHTN, increasing the likelihood of AHNT persisting on the skin surface and the health risk to the human being. Further, the interaction between amino acids and AHTN was investigated. AHTN could play bidirectional roles in damaging amino acids: the photosensitizer and reactive activator. As a photosensitizer, the 1O2 generated from the AHTN photosensitization was partly employed to oxidative damage amino acids. Furthermore, by combining experiments with quantum chemical computation, the carbonyl group of the activator AHTN was found to be the active site to activate the N-containing group of amino acids. The activation mechanism was the electron transfer between AHTN and amino acids.
Imines formed during the photochemical transformation of AHTN with histidine/glycine were the molecular initiating event for potential skin sensitization. This study reported for the first time that skin photosensitizer formation threatens human health during the photochemical transformation of Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation.Biosystems Science and Engineering, ETH Zurich.Materials Research Center, University of Freiburg.In recent years, biomarker diagnostics became an indispensable tool for the diagnosis of human disease, especially for the point-of-care diagnostics. An easy-to-use and low-cost sensor platform is highly desired to measure various types of analytes (e.g.
